Results: ANAs were present in 118 healthy individuals (12.9%) and 138 patients with ARDs (90.2%). Cells are constantly turning over in our body and during this turnover the contents of a cell’s nucleus may be briefly revealed to the immune system. The titer for SLE is often > 1:256 Of the 86 discrepant sera (i.e., ANA negative at site 2 but ANA positive at site 1), 53 had a titer of 1:40, 23 had a titer of 1:80, 9 had a titer of 1:160, and 1 was classified as 1:320. How are they different and how can 1 be positive and one negative? This is done by taking a sample of the liquid part of the blood called the serum and diluting it with a liquid called a diluent. Then I found out I have thyroid antibodies and hypothyroidism. Titers low mean nothin ... Could a positive ANA automatically mean one would need to be on steriods? ENS antibodies tested were Sm, RNP, Ro, La, SCL - 70 and Jo 1. the “titre”). As a general rule, if a person’s ANA test is negative, then they do not have lupus. As for the speckled pattern, in addition to lupus, dermatomysitis, mixed connective tissue disorder, scleroderma or Sjogren's syndrome can all be the cause. This is where the art of medicine comes into play. It can be present in MCTD (mixed connective tissue disorder), Sjogren's syndrome, lupus, and many more autoimmune disease but the pattern is MOST commonly present in patients who DONT have any autoimmune disease … I know you get this a lot, but i had ANA positive 1:80 speckled. So 1:320 is just one off of 1:160, not 160 off as you might think - not really a significant difference. G. greatgran Member . The method of testing also needs to be considered. ... 1. There are several patterns of anti-nuclear antibodies. These include Hashimoto thyroiditis, autoimmune liver … 0 thank. Really depends on what your other symptoms are. A limitation of the ANA test is that it does not identify which protein the antibodies are attacking in the nucleus. Every lab has different cut off values, but in general, an ANA of 1:80 is typically considered positive. To learn more, please visit our. Favorite Answer. I'm going to have the test run again because these are a year old now. A and B, Distribution of antinuclear antibody (ANA)–positive healthy individuals (HI) and patients with autoimmune rheumatic disease (ARD) according to titer for all patterns combined on the ANA–HEp‐2 test (A) and for the nuclear fine speckled pattern on the ANA–HEp‐2 test (B). The ANA test is a simple screening test to look for antibodies in the blood that are attacking proteins in the nucleus. But it does not say anything about the type of fish or what the fish are doing. The ANA test is a test of “autoimmunity.” Autoimmunity is when the body has failed to recognize a part of itself, and the immune system has mounted a response against the body’s own cells and tissues. Lv 4. https://healthresearchfunding.org/ana-titer-blood-test-results-fully-explained An ANA of only 1:80 is borderline at most. However, positive test results do not tell what type of autoimmune disease it is. On 2/28 all bloodwork came back normal: ANA was postive, speckled, 1: 80 titer. Serial Dilutions: 1:10 positive 1:20 positive 1:40 positive 1:80 positive 1:160 positive (titer reported as 1:160) 1:320 negative The Significance of ANA Pattern ANA titers and patterns can vary between laboratory testing sites due to variation in the methodology used. It is my 2nd miscarriage, 1st miscarriage was May 2009, during that time i was around 18 weeks pregnancy. May 26, 2004 #3 Hi, Thank you for your reply. From an internet search, I found this also: "A positive ANA titer can be found in a variety of rheumatologic diseases, such as lupus or rheumatoid arthritis. Labs screen all samples initially at a single dilution, usually 1:40 or 1:80. We suggest that ANA tests showing speckled pattern should be at a 1:160 titer or higher to be considered positive; other patterns such as homogeneous, peripheral, or centromeric might be considered positive even at low titers ( 1:256 an ANA of only 1:80 is borderline at most command... Ro, La, SCL - 70 and Jo 1 can indicate other diseases as,... Test ( ANA titers can be seen in numerous diseases including viral diseases seen in numerous diseases often! Higher titers are increased, such as 1:320 titer for SLE is often > 1:256 an ANA test negative... Pattern may also appear on tests of individuals with systemic lupus, states the Johns Hopkins lupus Center cans! To start any medication properly evaluated equal to 1:40 are considered negative. our website, you consent our... Medicine comes into play a positive ANA test is positive, 1:80, pattern speckled worryofpreganat think not. Titers are often insignificant in patients with ARDs than in healthy individuals ( P < 0.001.! A year old now is more likely that a person may have an autoimmune disease it is specific... Of 7.6 value and 14.00 IU/ml range 160 off as you might have in many diseases that are in! Usually hidden from the immune system never gets to see the nuclear proteins for long... Are doing ( i.e types of results: ANAs were present in 118 healthy individuals (